Blastocyst transfer may help in repeated IVF failure cases

Recurrent implantation failure may identified after three failed IVF cycles or after transfer of 10 high grade embryos. There are many different factors which may contribute for this recurrent IVF failure, such as parental chromosomal translocations, abnormal uterine anatomy , hydrosalpinx, or inadequate  culture conditions or embryo transfer techniques.

Failure may be due to factors with the “Seed,Soil or the Cultivator”

Some studies have suggested that local injury of the endometrium by means of a catheter or hysteroscopy can induce an inflammatory response that may facilitate the preparation for implantation.

Artificial rupture of the covering of the embryo ( Zona pellucida) may improve implantation: Assisted Hatching, but is still not proved.

Pre-implantation genetic screening of the embryos is now a day used to get and select best embryos. But this strategy did not show any improvement in patient outcome  and did not show any significant difference on clinical pregnancy rates.

A few studies have reported that congenital and acquired prothromotic conditions are more prevalent in women with recurrent implantation failure. Therefore use of low molecular weight heparin (LMWH) and mini dosage of aspirin on patients with thrombophilia and recurrent implantation failure has been discussed, but large studies are required to prove them .

Finally, another possible strategy is to extend embryo culture to blastocyst stage, aiming to improve embryo selection and uterine receptivity

Can fertility be preserved by Cryopreservation technology

Cryopreservation technology can be applied to Sperm, Embryo and Oocytes

The advantage of Sperm preservation is , easy to obtain in most patients, It has excellent results, and having a long track record of good success, but he bad part is , it is only for the male.

On the other hand , Embryo cryopreservation or freezing advantages are , excellent results in young patients and again a long good an successful track record. But the disadvantages are , it requires in vitro fertilization to obtain eggs, and may be financially costly and requires female patients to choose sperm donor before cryopreservation.

In Oocyte freezing or cryopreservation, the advantages are very good result in young patients and it does not require female patients to choose sperm donor before cryopreservaion, but bad part is, again it requires IVF to obtain eggs, it may be financially costly and relatively short track record.

Even ovarian cryopreservation is on its way, thin slices are stored  and frozen.

Freezing or cryopreservation is now a days are done by rapid freezing, a procedure called ” Vitrification” 

In our center, Ideal Fertility  Center , we are doing vitrification of embryos since long with very good result of “Blastocyst Freezing” with almost 100% recovery for transfer.

Sperms are stored long and before actual IVF procedure, so that if the male partner is not able to provide semen on the oocyte recovery day, we can use the frozen ones successfully.

We have started oocyte vitrification, and achieved one pregnancy too, but we are at a beginning , in future , soon we are starting our ” Egg Banking” services for those females, who because of their carrier demand can not reproduce in younger age and they can have their own child in later part of life.